FOR RESEARCH PURPOSES ONLY-This compound is not FDA approved. All data presented is from clinical trials for educational reference
AOD9604 6mg
Bronchogen is a peptide bioregulator derived from bronchial tissue extracts studied for its influence on respiratory epithelial regeneration and alveolar cell gene expression. It modulates peptide-mediated cytokine signaling, smooth muscle tone, and oxidative response pathways. Bronchogen is used in research investigating pulmonary peptide regulation and airway cellular homeostasis.
For research use only. Not for human consumption.
References:
Khavinson VK et al., Bull Exp Biol Med, 2004 137(5):597–600
Trofimova SV et al., Adv Gerontol, 2015 28(3):432–439
Linkova NS et al., Biochemistry (Moscow), 2012 77(7):874–881
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| Molecular Formula | C₁₆H₁₆ClN₃O₂S |
| Molecular Weight | 380.2 |
| Monoisotopic Mass | 378.9949032 |
| Polar Area | 87.1 |
| Complexity | 515 |
| XLogP | 4.1 |
| Heavy Atom Count | 24 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 4 |
| PubChem LCSS | D-304 Laboratory Chemical Safety Summary |
| CID | 60923806 |
| InChI | InChI=1S/C16H16ClN3O2S... |
| InChIKey | WEDMLYRBQUTKOAX-UHFFFAOYSA-N |
| Isomeric SMILES | C1=CC(...) |
| Canonical SMILES | C1=CC(...) |
| IUPAC Name | 4-chloro-N-[2-(4-iso...)]benzamide |
2D Structure
Overview
0-304 is a synthetic small-molecule AMPK (5′ AMP-activated protein kinase) activator developed for laboratory investigation of cellular energy-sensing pathways. AMPK functions as a conserved metabolic regulator that coordinates cellular responses to energetic stress by modulating mitochondrial activity, substrate utilization, and autophagic processes. In research settings, 0-304 is utilized as a biochemical probe to examine AMPK- dependent regulation of mitochondrial turnover, redox balance, and metabolic signaling under controlled experimental conditions.
Biochemical Characteristics
Source: PubChem
Chemical Formula: C,8H,CLN3O2S
Molecular Weight: 380.2 g/mol
PubChem CID: 50923806 CAS
No.: 1261289-04-6
Synonyms: 0-304 0-304
demonstrates physicochemical properties compatible with intracellular access and sustained AMPK phosphorylation in experimental model systems.
Research Applications
- AMPK-regulated metabolic signaling studies
- Mitochondrial biogenesis and mitophagy analysis
- Oxidative stress and redox homeostasis modeling
- Autophagy-linked transcriptional regulation
- Energy-sensing pathway interrogation in cellular and animal models
All applications are restricted to non-clinical laboratory research environments.
Pathway / Mechanistic Context
AMPK acts as a heterotrimeric kinase complex that responds to cellular energy depletion by promoting ATP-generating catabolic pathways while suppressing energy-consuming anabolic processes. O-304 enhances AMPK signaling by stabilizing phosphorylation of the catalytic α-subunit, thereby extending the active signaling state.
Downstream effects observed in experimental systems include modulation of fatty acid oxidation, glucose transporter trafficking, mitochondrial quality control, and transcriptional regulation of autophagy-associated genes.
Preclinical Research Summary
Preclinical investigations utilizing cellular assays and rodent models have examined O-304-mediated AMPK activation in the context of mitochondrial metabolism, glucose handling, lipid utilization, and oxidative stress regulation. These studies document alterations in mitochondrial enzyme expression, respiratory capacity, and autophagic flux.
Additional experimental work has evaluated AMPK-dependent signaling in tissues characterized by high energetic demand, including skeletal muscle, renal epithelium, cardiac tissue, and neuronal systems.
AMPK-mediated regulation of mitochondrial and metabolic pathways
Source: Frontiers
Form & Analytical Testing
O-304 is supplied as a research-grade small-molecule compound. Identity and purity are verified using standard analytical methodologies, including chromatographic separation and mass-based characterization, to ensure suitability for laboratory research applications.
Referenced Citations
- Neelakantan H. et al., “Selective and membrane-permeable small-molecule inhibitors of nicotinamide N-methyltransferase reverse high-fat diet-induced obesity in mice,” Biochem Pharmacol, 2018.
- Pissios P., “Nicotinamide N-methyltransferase: more than a vitamin B3 clearance enzyme,” Trends Endocrinol Metab, 2017.
ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.
RUO Disclaimer
The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.
For Laboratory Research Only. Not for human use, medical use, diagnostic use, or veterinary use.
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